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Faculty of Biology, Chemistry & Earth Sciences

Cell Biology & Electron Microscopy – Prof. Dr. Benedikt Westermann / Prof. Dr. Stefan Geimer / Dr. Till Klecker

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Publications Ralf Braun

Publications (31 contributions in total)

External profiles:

ORCID; GoogleScholar; Clarivate Analytics: Publons / ResearcherID; Scopus: Mendeley / Scopus; EuropePMC; Impactstory; Loop; ResearchGate

Research articles (peer-reviewed):

13. Leibiger C.*, Deisel J.*, Aufschnaiter A., Ambros S., Tereshchenko M., Verheijen B.M., Büttner S., and Braun R.J.# TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity. Hum. Mol. Genet. 2018; . Free Full Text; PubMed.

12. Böckler S.*, Chelius X.*, Hock N.*, Klecker T, Wolter M., Weiss M., Braun R.J., and Westermann B.# Fusion, fission and transport control asymmetric inheritance of mitochondria and protein aggregates. J. Cell Biol. 2017; . Publisher's Site; PubMed.

11. Dumit V.I.#, Zerbes R.M., Kaeser-Pebernard S., Rackiewicz M., Wall M.T., Gretzmeier C., Küttner V., van der Laan M., Braun R.J., and Dengjel J.# Respiratory status determines the effect of emodin on cell viability. Oncotarget 2017; . Free Full Text; PubMed.

10. Braun R.J.*,#, Sommer C.*, Leibiger C.*, Gentier R.J.G.*, Dumit V.I., Paduch K., Eisenberg T., Habernig L., Trausinger G., Magnes C., Pieber T., Sinner F., Dengjel J., Van Leeuwen F.W., Kroemer G., and Madeo F.# Accumulation of basic amino acids at mitochondria dictates the cytotoxicity of aberrant ubiquitin. Cell Rep. 2015; 10(9): 1557-1571. Free Full Text; PubMed.

9. Imbeault E., Mahvelati T.M., Braun R., Gris P., and Gris D.# Nlrx1 regulates neuronal cell death. Mol. Brain 2014; 7(1): 90. Free Full Text; PubMed.

8. Büttner S., Habernig L., Broeskamp F., Ruli D., Vögtle F.N., Vlachos M., Macchi F., Küttner V., Carmona-Gutierrez D., Eisenberg T., Ring J., Markaki M., Taskin A.A., Benke S., Ruckenstuhl C., Braun R., Van den Haute C., Bammens T., Van der Perren A., Fröhlich K.-U., Winderickx J., Kroemer G., Baekelandt V., Tavernarakis N., Kovacs G.G., Dengjel J., Meisinger C., Sigrist C. #, and Madeo F. # Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J. 2013; 32(23): 3041-3054. Free Full Text; PubMed.

7. Braun R.J., Sommer C., Carmona-Gutierrez D., Khoury C.M., Ring J., Büttner S., and Madeo F.# Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast. J. Biol. Chem. 2011; 286(22): 19958-19972. Free Full Text; PubMed.

6. Carmona-Gutierrez D., Reisenbichler A., Heimbucher P., Bauer M.A., Braun R.J., Ruckenstuhl C., Büttner S., Eisenberg T., Rockenfeller P., Fröhlich K.-U., Kroemer G.#, and Madeo F.# Ceramide triggers metacaspase-independent mitochondrial cell death in yeast. Cell Cycle 2011; 10(22): 3973-3978. Publisher’s Site; PubMed.

5. Braun R.J.*, Zischka H.*,#, Madeo F., Eisenberg T., Wissing S., Büttner S., Engelhardt S.M., Büringer D., and Ueffing M. Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. J. Biol. Chem. 2006; 281(35): 25757-25767. Free Full Text; PubMed.

4. Zischka H.#, Braun R.J., Marantidis E.P., Büringer D., Hauck S.M., Bornhövd C., Demmer O., Gloeckner C.J., Reichert A.S., Madeo F., and Ueffing M. Differential analysis of Saccharomyces cerevisiae mitochondria by free-flow electrophoresis. Mol. Cell Proteomics 2006; 5(11): 2185-2200. Free Full Text; PubMed.

3. Rinnerthaler M., Jarolim S., Heeren G., Palle E., Perju S., Klinger H., Bogengruber E., Madeo F., Braun R.J., Breitenbach-Koller L., Breitenbach M., and Laun P.# MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Biochim. Biophys. Acta. 2006; 1757(5-6): 631-638. Free Full Text; PubMed.

2. Gloeckner C.J., Kinkl N., Schumacher A., Braun R.J., O'Neill E., Meitinger T., Kolch W., Prokisch H., and Ueffing M.# The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum. Mol. Genet. 2006; 15(2): 223-232. Free Full Text; PubMed.

1. Zischka H., Weber G., Weber P.J., Posch A., Braun R.J., Büringer D., Schneider U., Nissum M., Meitinger T., Ueffing M., and Eckerskorn C.# Improved proteome analysis of Saccharomyces cerevisiae mitochondria by free-flow electrophoresis. Proteomics 2003; 3(6): 906-916. Publisher’s Site; PubMed.

Reviews (peer-reviewed):

9. Carmona-Gutierrez D., Bauer M.A., Zimmermann A., Aguilera A., Austriaco N., Ayscough K., Balzan R., Bar-Nun S., Barrientos A., Belenky P., Blondel M., Braun R.J., Breitenbach M., Burhans W.C., Büttner S. et al. Guidelines and recommendations on yeast cell death nomenclature. Microb. Cell 2018; 5(1): 4-31. Free Full Text; PubMed.

8. Braun R.J.# and Westermann B#. With the Help of MOM: Mitochondrial Contributions to Cellular Quality Control. Trends Cell Biol. 2017; 27(6): 441-452. Publisher’s Site; Science Direct; PubMed.

7. Braun R.J.#. Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins. Front. Mol. Neurosci. 2015; 8:8. Free Full Text; PubMed.

6. Mirisola M.G.*,#, Braun R.J.*,#, and Petranovic D.* ,# Approaches to study yeast cell aging and death. FEMS Yeast Res. 2014; 14(1): 109-118. Free Full Text; PubMed.

5. Braun R.J.#. Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration. Front. Oncol. 2012; 2:182. Free Full Text; PubMed.

4. Braun R.J.#, and Westermann B. Mitochondrial dynamics in yeast cell death and aging. Biochem. Soc. Trans. 2011; 39(5): 1520-1526. Publisher’s Site; PubMed.

3. Braun R.J., Büttner S., Ring J., Kroemer G., and Madeo F.# Nervous yeast – Modeling neurotoxic cell death. Trends Biochem. Sci. 2010; 35(3): 135-44. Publisher's Site; Science Direct; PubMed.

2. Braun R.J.#, and Zischka H. Mechanisms of Cdc48/VCP-mediated cell death – From yeast apoptosis to human disease. Biochim. Biophys. Acta 2008; 1783(7): 1418-1435. Free Full Text; PubMed.

1. Braun R.J., Kinkl N., Beer M., and Ueffing M.# Two-dimensional electrophoresis of membrane proteins. Anal. Bioanal. Chem. 2007; 389(4): 1033-1045. Publisher’s Site; PubMed.


3. Leibiger C.*, Deisel J.*, Aufschnaiter A., Ambros S., Tereshchenko M., Verheijen B.M., Büttner S., and Braun R.J.# Endolysosomal pathway activity protects cells from neurotoxic TDP-43. Microb. Cell 2018; 5(4): 212-214. Free Full Text; PubMed.

2. Klecker T.#, Braun R.J., and Westermann B. Lipid Droplets Guard Mitochondria during Autophagy. Dev. Cell. 2017; 42(1): 1-2. Publisher's Site; Science Direct; PubMed.

1. Braun R.J.*,#, Sommer C.*, Leibiger C.*, Gentier R.J.G.*, Dumit V.I., Paduch K., Eisenberg T., Habernig L., Trausinger G., Magnes C., Pieber T., Sinner F., Dengjel J., Van Leeuwen F.W., Kroemer G., and Madeo F.# Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast. Microb. Cell 2015; 2(4): 136-138. Free Full Text; PubMed.

Meeting reports :

4. Braun R.J.*,#, Zerbes R.M., Steinberg F., Gris D., and Dumit V.I. # Threading Granules in Freiburg: 2nd International Symposium on “One Mitochondrion, Many Diseases – Biological and Molecular Perspectives”, a FRIAS Junior Researcher Conference, Freiburg im Breisgau, Germany, March 9th/10th, 2016; Microb. Cell 2016; 3(11): 434-437. Free Full Text; PubMed.

3. Braun R.J.*,#, Dumit V.I.*, Monpays C., Roucou X., Serrano D., St-Pierre J., Waters P.J., Bates I., and Gris D.# Struggling for breath in Sherbrooke: 1st Symposium on “One mitochondrion, many diseases” in Sherbrooke, Québec, Canada, March 2015; Microb. Cell 2015; 2(6): 208-213. Free Full Text; PubMed.

2. Carmona-Gutierrez D., Ruckenstuhl C., Bauer M.A., Netzberger C., Eisenberg T., Braun R.J., Rockenfeller P., Khoury C.M., Moitzi B., Sommer C., Ring J., Schroeder S., Habernig L., Mazzoni C., Winderickx J., Gourlay C.W., and Madeo F.# A new Canterbury tale: the eighth International Meeting on Yeast Apoptosis in Canterbury, UK, 2-6 May 2011. Cell Death Differ. 2011; 18(12): 1948-1949. Free Full Text, PubMed.

1. Ring J., Moitzi B., Bauer M., Braun R.J., and Madeo F.# Killing and Chilling in Graz. 7th International Meeting on Yeast Apoptosis, Austria, Sept. 2009. Cell Death Differ. 2010; 17(5): 895-898. Publisher’s Site.

Book sections:

2. Braun R.J.*, Kinkl N.*, Zischka H., and Ueffing, M.# 16-BAC/SDS-PAGE analysis of membrane proteins of yeast mitochondria purified by free flow electrophoresis. Methods in the Proteomics of Membrane Proteins, Methods Mol. Biol. 2009; 528: 83-107. Publisher’s Site; PubMed.

1. Zischka H.*, Kinkl N.*, Braun R.J., and Ueffing M.# Purification of Saccharomyces cerevisiae mitochondria by zone-electrophoresis in free flow device (ZE-FFE). Organelle Proteomics, Methods Mol. Biol. 2008; 432: 51-64. Publisher’s Site; PubMed.

* Equally contributing authors, # Corresponding authors

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