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Faculty of Biology, Chemistry & Earth Sciences

Cell Biology & Electron Microscopy – Prof. Dr. Benedikt Westermann / Prof. Dr. Stefan Geimer / Dr. Till Klecker

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Publications Stefan Geimer

65. Lechado-Terradas A., Schepers S., Zittlau K.I., Sharma K., Ok O., Fitzgerald J.C., Geimer S., Westermann B., Macek B. & Kahle P.J. (2022) Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy, Autophagy Reports 1:576-602., DOI: 10.1080/27694127.2022.2143214

64. Reiter B., Rosenhammer L., Marino G., Geimer S., Leister D. & Rühle T. (2022) CGL160-mediated recruitment of the coupling factor CF1 is required for efficient thylakoid ATP synthase assembly, photosynthesis, and chloroplast development in Arabidopsis, Plant Cell, koac306, https://doi.org/10.1093/plcell/koac306

63. van den Hoek H., Klena N., Jordan M. A., Alvarez Viar G., Righetto R. D., Schaffer M., Erdmann P. S., Wan W., Geimer S., Plitzko J. M., Baumeister W., Pigino G., Hamel V., Guichard P., Engel B. D. (2022) In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains. Science. 377:543-548., doi: 10.1126/science.abm6704

62. Mickoleit F., Jörke C., Geimer S., Maier D. S., Müller J. P., Demut J., Gräfe C., Schüler D., & Clement J. H. (2021) Biocompatibility, uptake and subcellular localization of bacterial magnetosomes in mammalian cells. Nanoscale Adv., DOI: 10.1039/d0na01086c

61. Klena N., Le Guennec M., Tassin A-M., van den Hoek H., Erdmann P. S., Schaffer M., Geimer S., Aeschlimann G., Kovacik L., Sadian Y., Goldie K. N., Stahlberg H., Engel B. D., Hamel V., & Guichard P. (2020) Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography. EMBO J. 39:e106246.

60. Wang P., Richter A.S., Kleeberg J.R.W., Geimer S., & Grimm B. (2020) Post-translational coordination of chlorophyll biosynthesis and breakdown by BCMs maintains chlorophyll homeostasis during leaf development. Nat. Commun. 11:1254.

59. Fischer C. B., Körsten S., Rösken L. M., Cappel F., Beresko C., Ankerhold G., Schönleber A., Geimer S., Ecker D. & Wehner S. (2019) Cyanobacterial promoted enrichment of rare earth elements europium, samarium and neodymium and intracellular europium particle formation. RSC Adv. 9:32581-32593.

58. Frikstad K.-A. M., Molinari E., Thoresen M., Ramsbottom S. A., Hughes F., Letteboer S. J.F., Gilani S., Schink K. O., Stokke T., Geimer S., Pedersen L. B., Giles R. H., Akhmanova A., Roepman R., Sayer J. A. & Patzke S.  (2019) A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Rep. 28:1907–1922.

57. Giordano T., Gadadhar S., Bodakuntla S., Straub J., Leboucher S., Martinez G., Chemlali W., Bosc C., Andrieux A., Bieche I., Arnoult C., Geimer S., & Janke C. (2019) Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility. J. Cell Sci. 132: jcs226951. doi: 10.1242/jcs.226951

56. Küken A., Sommer F., Yaneva-Roder L., Mackinder L. C. M., Höhne M., Geimer S., Jonikas M. C., Schroda M., Stitt M., Nikoloski Z., & Mettler-Altmann T. (2018) Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts. eLife 2018;7:e37960

55. Eisenhut M., Hoecker N., Schmidt S. B., Basgaran R. M., Flachbart S., Jahns P., Eser T., Geimer S., Husted S., Weber A. P. M., Leister D., & Schneider A. (2018). The plastid envelope CHLOROPLAST MANGANESE TRANSPORTER1 is essential for manganese homeostasis in Arabidopsis. Mol. Plant 11:955-969.

54. Mönnich M., Borgeskov L., Breslin L., Jakobsen L., Rogowski M., Doganli C., Schrøder J.M., Mogensen J. B., Blinkenkjær L., Harder L. M., Lundberg E., Geimer S., Christensen S. T., Andersen J. S., Larsen L. A. & Pedersen L. B. (2018). CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium. Cell Rep. 22:2584–2592.

53. Rochert A. S., Rösken L. M., Fischer C. B., Schönleber A., Ecker D., van Smaalen S., Geimer S. & Wehner S. (2017). Bioselective synthesis of gold nanoparticles from diluted mixed Au, Ir, and Rh ion solution by Anabaena cylindrica. J. Nanopart. Res. 19:355. doi.org/10.1007/s11051-017-4039-8

52. Unger A.-K., Geimer S., Harner M., Neupert W. & Westermann B. (2017). Analysis of yeast mitochondria by electron microscopy. Methods Mol. Biol. 1567:293-314.

51. Heimerl T., Flechsler J., Pickl C., Heinz V., Salecker B., Zweck J., Wanner G., Geimer S., Samson R.Y., Bell S.D., Huber H., Wirth R., Wurch L., Podar M. & Rachel R (2017). A Complex Endomembrane System in the Archaeon Ignicoccus hospitalis Tapped by Nanoarchaeum equitans. Front. Microbiol. 8:1072. doi: 10.3389/fmicb.2017.01072

50. Borken W., Horn M. A., Geimer S., Bahamonde Aguilar N. A. & Knorr K.-H. (2016) Associative nitrogen fixation in nodules of the conifer Lepidothamnus fonkii (Podocarpaceae) inhabiting ombrotrophic bogs in southern Patagonia. Sci. Rep. 6: 39072. doi:10.1038/srep39072

49. Harner M.E., Unger A.-K., Geerts W.J.C., Mari M., Izawa T., Stenger M., Geimer S., Reggiori F., Westermann B. & Neupert, W. (2016). An evidence based hypothesis on the existence of two pathways of mitochondrial cristae formation. eLife 2016;5:e18853

48. Mackinder L. C. M., Meyer M. T., Mettler-Altmann T., Chen V. K., Mitchell M. C., Caspari O., Freeman Rosenzweig E. S., Pallesen L., Reeves G., Itakura A., Roth R., Sommer F., Geimer S., Mühlhaus T., Schroda M., Goodenough U., Stitt M., Griffiths H. & Jonikas M. C. (2016) A repeat protein links Rubisco to form the eukaryotic carbon-concentrating organelle. PNAS doi: 10.1073/pnas.1522866113

47. Schneider A., Steinberger I., Herdean A., Gandini C., Eisenhut M., Kurz S., Morper A., Hoecker N., Rühle T., Labs M., Flügge U. I., Geimer S., Schmidt S. B., Husted S., Weber A. P. M., Spetea C., & Dario Leister (2016) The Evolutionarily Conserved Protein PHOTOSYNTHESIS AFFECTED MUTANT71 is Required for Efficient Manganese Uptake at the Thylakoid Membrane in Arabidopsis. Plant Cell 28:892–910

46. Rösken L. M., Cappel F., Körsten S., Fischer C. B., Schönleber A., van Smaalen S., Geimer S., Beresko C., Ankerhold G. & Wehner S. (2016) Time-dependent growth of crystalline Au0-nanoparticles in cyanobacteria as self-reproducing bioreactors: 2. Anabaena cylindrica. Beilstein J. Nanotechnol. 7: 312-327

45. Muranaka L. S., Rütgers M., Bujaldon S., Heublein A., Geimer S., Wollman F.-A. & Schroda M. (2016) TEF30 interacts with photosystem II monomers and is involved in the repair of photodamaged photosystem II in Chlamydomonas reinhardtii. Plant Physiol. 170:821–840

44. Eitzinger N., Wagner V., Weisheit W., Geimer S., Boness D., Kreimer G. & Mittag M. (2015) Proteomic Analysis of a Fraction with Intact Eyespots of Chlamydomonas reinhardtii and Assignment of Protein Methylation. Front. Plant Sci. 6:1085. doi: 10.3389/fpls.2015.01085

43. Sternemalm J., Geimer S., Frikstad K.-A. M., Schink K. O., Stokke T. & Patzke S. (2015). CSPP-L associates with the desmosome of polarized epithelial cells and is required for normal spheroid formation. PLoS One 10(8): e0134789. doi: 10.1371/journal.pone.0134789

42. Hemme D., Veyel D., Mühlhaus T., Sommer F., Jüppner J., Unger A.-K., Sandmann M., Fehrle I., Schönfelder S., Steup M., Geimer S., Kopka J., Giavalisco P. & Schroda M. (2014). Systems-wide analysis of acclimation responses to long-term heat stress and recovery in the photosynthetic model organism Chlamydomonas reinhardtii. Plant Cell 26:4270-4297

41. Harner M., Unger A.-K., Izawa T., Walther D., Özbalci C., Geimer S., Reggiori F., Brügger B., Mann M., Westermann B. & Neupert W. (2014). Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. eLife, 3:e01684

40. Rösken L.M., Körsten S., Fischer C.B., Schönleber A., van Smaalen S., Geimer S. & Wehner S. (2014) Time-dependent growth of crystalline Au0-nanoparticles in cyanobacteria as self-reproducing bioreactors: 1. Anabaena spec. J. Nanopart. Res. 16:2370

39. Schneider A., Steinberger I., Strissel H, Kunz H.-H., Manavski N., Meurer J., Burkhard G., Jarzombski S., Schünemann D., Geimer S., Flügge U.-I. & Leister D. (2014) The Arabidopsis Tellurite resistance C protein together with ALB3 is involved in photosystem II protein synthesis. Plant J. 78:344-356

38. Kypri E., Christodoulou A., Maimaris G., Lethan M., Markaki M., Lysandrou C., Lederer C.W., Tavernarakis N., Geimer S., Pedersen L.B. & Santama N. (2014) The nucleotide‑binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Cell. Mol. Life Sci. 71:517-538

37. Weber M., Deinlein U., Fischer S., Rogowski M., Geimer S., Tenhaken R. & Clemens S. (2013) A mutation in the Arabidopsis thaliana cell wall biosynthesis gene pectin methylesterase 3 as well as its aberrant expression cause hypersensitivity specifically to Zn. Plant J. 76:151-164

36. Rogowski M., Scholz D., & Geimer S. (2013) Electron Microscopy of Flagella, Primary Cilia, and Intraflagellar Transport in Flat-Embedded Cells. In: Methods in Enzymology (W. F. Marshall, ed.), Vol. 524, pp. 243-263, Academic Press

35. Engel B.D., Ishikawa H., Wemmer K.A., Geimer S., Wakabayashi K.-i., Hirono M., Craige B., Pazour G.J., Witman G.B., Kamiya R., & Marshall W.F. (2012) The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function. J. Cell Biol. 199:151-167

34. Nordhues A., Schöttler M.A., Unger A.-K., Geimer S., Schönfelder S., Schmollinger S., Rütgers M., Finazzi G., Soppa B., Sommer F., Mühlhaus T., Roach T. Krieger-Liszkay A., Lokstein H., Crespo J.L., & Schroda M. (2012) Evidence for a role of VIPP1 in the structural organization of the photosynthetic apparatus in Chlamydomonas. Plant Cell 24:637-659

33. Breuers F.K.H.*, Bräutigam A.*, Geimer S.*, Welzel U.Y., Stefano G., Renna L., Brandizzi F., & Weber A.P. (2012) Dynamic remodeling of the plastid envelope membranes – a tool for chloroplast envelope in vivo localizations. Front. Plant Sci. 3:7, *equal contribution

32. Schmitz J., Schöttler M.A., Krueger S., Geimer S., Schneider A., Kleine T., Leister D., Bell K., Flügge U.-I. & Häusler R.E. (2012) Defects in leaf carbohydrate metabolism compromise acclimation to high light and lead to a high chlorophyll fluorescence phenotype in Arabidopsis thaliana. BMC Plant. Biol. 12:8

31. Leal-Egaña A., Lang G., Mauerer C., Wickinghoff J., Weber M., Geimer S., & Scheibel T. (2012) Interactions of Fibroblasts with Different Morphologies Made of an Engineered Spider Silk Protein. Adv. Eng. Mater. 14:B67-B75

30. Diener D.R., Yang P., Geimer S., Cole D.G., Sale W.S., & Rosenbaum J.L. (2011) Sequential assembly of flagellar radial spokes. Cell Motil. Cytoskeleton 68:389-400

29. Schrøder J.M., Larsen J., Komarova Y., Akhmanova A., Thorsteinsson R.I., Grigoriev I., Manguso R., Christensen S.T., Pedersen S.F., Geimer S.*, & Pedersen L.B.* (2011) EB1 and EB3 promote cilia biogenesis by several centrosome-dependent mechanisms. J. Cell Sci. 124:2539-2551, *shared senior authorship

28. Prabhakar V., Löttgert T., Geimer S., Dörmann P., Krüger S., Vijayakumar V., Schreiber L., Göbel C., Feussner K., Feussner I., Marin K., Staehr P., Bell K., Flügge U.-I., & Häusler R. E. (2010) Phosphoenolpyruvate Provision to Plastids Is Essential for Gametophyte and Sporophyte Development in Arabidopsis thaliana. Plant Cell 22:2594-2617

27. Fan Z.-C., Behal R.H., Geimer S., Wang Z., Williamson S.M., Zhang H., Cole D.G., & Qin H. (2010) Chlamydomonas IFT70/CrDYF-1 Is a Core Component of IFT Particle Complex B and Is Required for Flagellar Assembly. Mol. Biol. Cell. 21:2696-2706

26. Ehses S., Raschke I., Mancuso G., Bernacchia A., Geimer S., Tondera D., Martinou J.-C., Westermann B., Rugarli E.I., & Langer T. (2009) Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J. Cell Biol. 187:1023-1036

25. Geimer S. (2009) Immunogold Labeling of Flagellar Components In Situ. In: Methods in Cell Biology (S.M. King and G.J. Pazour, eds.), Vol. 91, pp. 63-80, Academic Press, San Diego

24. Pigino G.*, Geimer S.*, Lanzavecchia S., Paccagnini E., Cantele F., Diener D.R., Rosenbaum J.L., & Lupetti P. (2009) Electron-tomographic Analysis of Intraflagellar Transport Particle Trains in situ. J. Cell Biol. 187:135-148, *equal contribution

23. Keller L.C., Geimer S., Romijn E., Yates III J., Zamora I., & Marshall W.F. (2009) Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Mol. Biol. Cell 20:1150-1166

22. Häusler R. E., Geimer S., Kunz H. H., Schmitz J., Dormann P., Bell K., Hetfeld S., Guballa A., & Flügge U.-I. (2009) . Chlororespiration and Grana Hyperstacking: How an Arabidopsis Double Mutant Can Survive Despite Defects in Starch Biosynthesis and Daily Carbon Export from Chloroplasts. Plant Physiol. 149:515-533

21. Merkwirth C., Dargazanli S., Tatsuta T., Geimer S., Löwer B., Wunderlich F. T., von Kleist-Retzow J.-C., Waisman A., Westermann B. & Langer T. (2008) Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes & Dev. 22: 476-488

20. Feldman J. L., Geimer S. & Marshall W.F. (2007) The Mother Centriole Plays an Instructive Role in Defining Cell Geometry . PLoS Biol. 5(6): e149 doi:10.1371/journal.pbio.0050149

19. Dürr M., Escobar-Henriques M., Merz S., Geimer S., Langer T. & Westermann B. (2006) Non-redundant roles of mitochondria-associated F-box proteins, Mfb1 and Mdm30, in maintenance of mitochondrial morphology in yeast. Mol. Biol. Cell 17:3745-3755

18. Schmidt M., Geßner G., Luff M., Heiland I., Wagner V., Kaminski M., Geimer S., Eitzinger N., Reißenweber T., Voytsekh O., Fiedler M., Mittag M. & Kreimer G. (2006) Proteomic analysis of the eyespot of Chlamydomonas reinhardtii provides novel insights into its components and tactic movements. Plant Cell 18:1908-1930

17. Ziegler J., Viehrig C., Geimer S., Rösch P. & Schwarzinger S. (2006) Putative aggregation initiation sites in prion protein. FEBS Lett. 580:2033-2040

16. Pedersen L. B.*, Geimer S.* & Rosenbaum J. L. (2006) Dissecting the molecular mechanisms of intraflagellar transport in Chlamydomonas. Curr. Biol. 16:450-459, *equal contribution

15. Geimer S. & Melkonian M. (2005) Centrin scaffold in Chlamydomonas reinhardtii revealed by immunoelectron microscopy. Eukaryot. Cell 4:1253-1263

14. Niewiadomski P., Knappe S., Geimer S., Fischer K., Schulz B., Unte U. S., Rosso M. G., Ache P., Flügge U. I. & Schneider A. (2005) The Arabidopsis plastidic Glucose 6-Phosphate/Phosphate translocator GPT1 is essential for pollen maturation and embryo sac development. Plant Cell 17:760-775

13. Pedersen L. B., Miller M. S., Geimer S., Leitch J. M., Rosenbaum J. L. & Cole D. G. (2005) Chlamydomonas IFT172 is encoded by FLA11, interacts with CrEB1, and regulates IFT at the flagellar tip. Curr. Biol. 15:262-266

12. Gutensohn M., Pahnke S., Kolukisaoglu Ü., Schulz B., Schierhorn A., Voigt A., Hust B., Rollwitz I., Stöckel J., Geimer S., Albrecht V., Flügge U. I. & Klösgen R. B. (2004) Characterization of a T-DNA insertion mutant for the protein import receptor atToc33 from chloroplasts. Mol. Genet. Genomics 272:379-396

11. Geimer S. & Melkonian M. (2004) The ultrastructure of the Chlamydomonas reinhardtii basal apparatus: identification of an early marker of radial asymmetry inherent in the basal body. J. Cell Sci. 117:2663-2674

10. Qin H., Diener D. R., Geimer S., Cole D. G., & Rosenbaum J.L. (2004) Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body. J. Cell Biol. 164:255-266

9. Pedersen L. B., Geimer S., Sloboda R. D., & Rosenbaum J. L. (2003) The microtubule plus end-tracking protein EB1 is localized to the flagellar tip and basal bodies in Chlamydomonas reinhardtii Curr. Biol. 13:1969-1974

8. Pfannenschmid F., Wimmer V. C., Rios R.-M., Geimer S., Kröckel U., Leiherer A., Haller K., Nemcová Y. & Mages W. (2003) Chlamydomonas DIP13 and human NA14: a new class of proteins associated with microtubule structures is involved in cell division. J. Cell Sci. 116:1449-1462

7. Ruiz-Binder N., Geimer S., & Melkonian M. (2002) In vivo localization of centrin in the green alga Chlamydomonas reinhardtii. Cell Motil. Cytoskeleton 52:43-55

6. Lechtreck K.-F. & Geimer S. (2000) Distribution of polyglutamylated tubulin in the flagellar apparatus of green flagellates. Cell Motil. Cytoskeleton 47:219-235

5. Melkonian M., Geimer S., Steinkötter J. & Lechtreck K.-F. (1998) Towards a molecular map of the algal basal apparatus. In: Progress in Botanical research. Proceedings of the 1st Balkan Botanical Congress ( Tsekos I., Moustakas M., eds.), pp. 391-398, Dordrecht: Kluwer academic publishers

4. Geimer S., Lechtreck K.-F. & Melkonian M. (1998) A novel basal apparatus protein of 90 kD (BAp90) from the flagellate green alga Spermatozopsis similis is a component of the proximal plates and identifies the d (dexter)-surface of the basal body. Protist 149:173-184

3. Geimer S., Clees J., Melkonian M. & Lechtreck K.-F. (1998) A novel 95 kD protein is located in a linker between cytoplasmic microtubules and basal bodies in a green flagellate and forms striated fibers in vitro. J. Cell Biol. 140:1149-1158

2. Geimer S., Teltenkötter A., Plessmann U., Weber K. & Lechtreck K.-F. (1997) Purification and characterization of basal apparatuses from a flagellate green alga. Cell Motil. Cytoskeleton 37:72-85

1. Geimer S., Lechtreck K.-F. & Melkonian M. (1997) The cytoskeleton of the naked green flagellate Spermatozopsis similis (Chlorophyta): analysis of isolated basal apparatuses in the parallel configuration. J. Phycol. 33:241-253

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